Gene Cutler, PhD — Computational Biologist

Journal Publications

Potent GCN2 inhibitor capable of reversing MDSC-driven T cell suppression demonstrates in vivo efficacy as a single agent and in combination with anti-angiogenesis therapy
Journal of Medicinal Chemistry | 2022

EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22
PLoS Pathogens | 2022

Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4
L Marshall, S Marubayashi, A Jorapur, A Jacobson, M Zibinsky, O Robles, D Hu, J Jackson, D Pookot, J Sanchez, M Brovarney, A Wadsworth, D Chian, D Wustrow, P Kassner, Gene Cutler, B Wong, D Brockstedt, O Talay
Journal for Immunotherapy of Cancer | 11/2020

Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity in Vitro and in Vivo
Y Ohol, M Sun, Gene Cutler, P Leger, D Hu, B Biannic, P Rana, C Cho, S Jacobson, S Wong, J Sanchez, N Shah, D Pookot, B Abraham, K Young, S Suthram, L Marshall, D Bradford, N Kozon, X Han, A Okano, J Maung, C Colas, J Schwarz, D Wustrow, D Brockstedt, P Kassner
Molecular Cancer Therapeutics | 10/2020

Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors
O Robles, J Jackson, L Marshall, O Talay, D Chian, G Cutler, R Diokno, D Hu, S Jacobson, E Karbarz, P Kassner, J Ketcham, J McKinnell, C Meleza, M Reilly, E Riegler, H Shunatona, A Wadsworth, A Younai, D Brockstedt, D Wustrow, M Zibinsky
Journal of Medicinal Chemistry | 7/2020

Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4
L Marshall, S Marubayashi, A Jorapur, A Jacobson, M Zibinsky, O Robles, Dennis X Hu, J Jackson, D Pookot, J Sanchez, M Brovarney, A Wadsworth, D Chian, D Wustrow, P Kassner, G Cutler, B Wong, D Brockstedt, O Talay
Journal for Immunotherapy of Cancer | 11/2020

Targeting The Stress Response Kinase GCN2 To Restore Immunity In The Tumor Microenvironment
L Marshall, B Ravishankar, L Adusumilli, M Zibinsky, D Pookot, E Huang, O Talay, S Suthram, J Jackson, G Shibuya, P Leger, P Tivitmahaisoon, A Okal, D Bradford, C Colas, G Cutler, J Schwartz, Wustrow, P Kassner, D Brockstedt
Journal for Immunotherapy of Cancer | 11/2019

Discovery of potent and selective inhibitors of USP7 with anti-tumor activity in vitro and in vivo
Y Ohol, M Sun, G Cutler, P Leger, D Hu, B Biannic, P Rana, C Cho, S Jacobson, S Wong, J Sanchez, an, K Young, A Okano, N Shah, B Abraham, D Pookot, J Maung, D Bradford, N Kozon, S Suthram, dusumilli, D Kaveri, O Talay, C Colas, A Kim, J Schwarz
Cancer Research | 7/2019

Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment
J Jackson, J Ketcham, A Younai, B Abraham, B Biannic, H Beck, M Bui, D Chian, G Cutler, R Diokno, u, S Jacobson, E Karbarz, P Kassner, L Marshall, J McKinnell, C Meleza, A Okal, D Pookot, M Reilly, obles, H Shunatona, O Talay, J Walker, A Wadsworth, D Wustrow, M Zibinsky
Journal of Medicinal Chemistry | 6/2019

FLX925 Is a Rationally Designed FLT3, CDK4/6 Inhibitor with a Desirable Resistance Profile
S Marubayashi, A Park, R Noubade, H Phan, G Cutler, P Kassner, JS Fridman
Blood | 12/2016

A Machine-Learning Analysis Suggests That FLX925, a FLT3/CDK4/6 Kinase Inhibitor, Is Potent Against FLT3-Wild Type Tumors Via Its CDK4/6 Activity
G Cutler, JS Fridman
Blood | 12/2016

Advancing therapeutic discovery through phenotypic screening of the extracellular proteome using hydrodynamic intravascular injection
H Baribault, JZ Majeti, H Ge, J Wang, Y Xiong, J Gardner, L Yang, J Gupte, Y Gong, Z Pan, G Cutler, P assner, H Tu, B Shan, X Wu, and Y Li
Expert opinion on therapeutic targets | 11/2014

Molecular signatures of the primitive prostate stem cell niche reveal novel mesenchymal-epithelial signaling pathways
R Blum, R Gupta, PE Burger, CS Ontiveros, SN Salm, X Xiong, A Kamb, H Wesche, L Marshall, G Cutler,
X Wang, J Zavadil, D Moscatelli, EL Wilson
PLoS One | 09/30/2010

Identification of transcriptional networks responding to pyrroloquinoline quinone dietary supplementation and their influence on thioredoxin expression, and the JAK/STAT and MAPK pathways
E Tchaparian, L Marshal, G Cutler, K Bauerly, W Chowanadisai, M Satre, C Harris, RB Rucker
Biochemical Journal | 08/01/2010

Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer
R Blum, R Gupta, PE Burger, CS Ontiveros, SN Salm, X Xiong, A Kamb, H Wesche, L Marshall, G Cutler,
X Wang, J Zavadil, D Moscatelli, EL Wilson
PloS One | 05/09/2009

Copy number variation in the mouse genome: implications for the mouse as a model organism for human disease
G Cutler, PD Kassner
Cytogenetics and Genome Research | 03/11/2009

Significant gene content variation characterizes the genomes of inbred mouse strains
G Cutler, LA Marshall, N Chin, H Baribault, PD Kassner
Genome Research | 01/12/2007

Impact of diet on hepatic gene expression in response to selected drugs and nutrients
E Tchaparian, K Bauerly, C Harris, M Satre, W Chowanadisai, G Cutler, L Marshall, A Mitchell, R Rucker
FASEB Journal | 03/2007

Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers
S Herter, D Piper, W Aaron, T Gabriele, G Cutler, P Cao, A Bhatt, Y Choe, C Craik, N Walker, D Meininger, T Hoey, R Austin
Biochemical Journal | 08/15/2005

Multiclass cancer classification and biomarker discovery using GA-based algorithms
JJ Liu, G Cutler, W Li, Z Pan, S Peng, T Hoey, L Chen, XB Ling
Bioinformatics | 06/01/2005

Elucidation of signaling properties of vasopressin receptor-related receptor 1 by using the chimeric receptor approach
J Gupte, G Cutler, JL Chen, H Tian
Proceedings of the National Academy of Sciences | 02/10/2004

A comparative analysis of HGSC and Celera human genome assemblies and gene sets
S Li, G Cutler, JJ Liu, T Hoey, L Chen, PG Schultz, J Liao, XB Ling
Bioinformatics | 09/01/2003

Comparative analysis of human genome assemblies reveals genome-level differences
S Li, J Liao, G Cutler, T Hoey, JB Hogenesch, MP Cooke, PG Schultz, XB Ling
Genomics | 08/31/2002

Identification and characterization of a melanin-concentrating hormone receptor
S An, G Cutler, JJ Zhao, SG Huang, H Tian, W Li, L Liang, M Rich, A Bakleh, J Du, JL Chen, K Dai Proceedings of the National Academy of Sciences | 06/19/2001

Adf-1 is a nonmodular transcription factor that contains a TAF-binding Myb-like motif
G Cutler, KM Perry, R Tjian
Molecular and cellular biology | 04/01/1998

Contacts in context: promoter specificity and macromolecular interactions in transcription
JA Goodrich, G Cutler, R Tjian
Cell | 03/22/1996